Publications
PUBLISHED PAPERS
CHIPS published papers
Donegan KL, Walker AS, Dunn D, Judd A, Pillay D, Menson E, Lyall H, Tudor-Williams G, Gibb DM on behalf of the Collaborative HIV Paediatric Study and the UK HIV Drug Resistance Database. The prevelence of Darunavir associated mutations in HIV-1 infected children in the UK. Antiviral Therapy - in press.
Judd A, Boyd K, Stohr W, Dunn D, Butler K, Lyall EGH, Sharland M, Shingadia D, Riordan A, Gibb DM. Effect of Tenofovir Disoproxil Fumarate (TDF) on risk of renal abnormality in HIV-1 infected children on antiretroviral therapy: a nested case-control study. AIDS 2010; 24(4): 525-534. (PubMed reference)
Judd A, Ferrand RA, Jungmann E, Foster C, Masters J, Rice B, Lyall H, Tookey PA, Prime K. Vertically acquired HIV diagnosed in adolescence and early adulthood in the UK and Ireland: findings from national surveillance. HIV Medicine 2009; 10: 253-256. (Download Paper)
Foster C, Judd A, Tookey P, Tudor-Williams G, Dunn D, Shingadia D, Butler K, Sharland M, Gibb D, Lyall H. Young people in the UK and Ireland with perinatally acquired HIV: the paediatric legacy for adult services. AIDS Patient Care and STDs 2009; 23(3): 159-166. (PubMed reference)
Kekitiinwa A, Lee KJ, Walker AS, Maganda A, Doerholt K, Kitaka S, Asiimwe A, Judd A, Musoke P, Gibb DM. Differences in factors associated with initial growth, CD4 and viral load response to ART in Ugandan and UK/Irish HIV-infected children. JAIDS 2008; 49(4): 384-392. (PubMed reference)
Riordan A, Judd A, Boyd K, Cliff D, Doerholt K, Lyall H, Menson E, Butler K, Gibb D. Tenofovir use in human immunodeficiency virus-1 infected children in the United Kingdom and Ireland. Paediatric Infectious Diseases Journal 2009; 28(3): 204-209.(PubMed reference)
Chakraborty R, Smith CJ, Dunn D, Green H, Duong T, Doerholt K, Riordan A, Lyall H, Tookey P, Butler K, Sabin C, Gibb DM, Pillay D. HIV-1 drug resistance in HIV-1 infected children in the United Kingdom from 1998 to 2004. Paediatric Infectious Disease Journal 2008; 27(5): 457-459. This is a non-final version of an article published in final form in Paediatric Infectious Disease Journal 2008; 27(5): 457-459. www.pidj.com (Download Paper)
Lee, KJ, Shingadia D, Pillay D, Walker AS, Riordan A, Menson E, Duong T, Tudor-Williams G, Gibb DM on behalf of the Collaborative HIV Paediatric Study (CHIPS) Steering Committee. Transient viral load increases in HIV-infected children in the UK and Ireland: what do they mean? Antiviral Therapy 2007; 12(6): 949-956. [This is the author's version of a work accepted for publication by International Medical Press. Changes resulting from the publishing process, including peer review, editing and formatting, might not be reflected in this document. A definitive version was published in Antiviral Therapy [Vol 12, Issue 6] © 2007 International Medical Press] (Download pre-publication paper)
Judd A, Doerholt K, Tookey PA, Sharland M, Riordan A, Menson E, Novelli V,
Lyall EG, Masters J, Tudor-Williams G, Duong T, Gibb DM. Morbidity, mortality,
and response to treatment by children in the United Kingdom and Ireland with
perinatally acquired HIV infection during 1996-2006: planning for teenage and
adult care. Clinical Infectious Diseases 2007;45(7):918-924. © 2007 by the
Infectious Diseases Society of America. (Download paper)
Menson EN, Walker AS, Sharland M, Wells C, Tudor-Williams G, Riordan FAI, Lyall EGH, Gibb DM for the Collaborative HIV Paediatric Study Steering Committee. Underdosing of antiretrovirals in UK and Irish children with HIV as an example of problems in prescribing medicines to children, 1997-2005: cohort study. British Medical Journal 2006; 332:1183-1187. (Download paper)
Doerholt K, Duong T, Tookey P, Butler K, Lyall H, Sharland M, Novelli V, Riordan A, Dunn D, Walker AS, Gibb DM. Outcomes for human immunodeficiency virus-1-infected infants in the United Kingdom and Republic of Ireland in the era of effective antiretroviral therapy. Pediatric Infectious Disease Journal 2006; 25: 420-426. (PubMed reference)
Walker AS, Doerholt K, Sharland M, Gibb DM, for the Collaborative HIV Paediatric Study (CHIPS) Steering Committee. Response to highly active antiretroviral therapy varies with age: the UK and Ireland Collaborative HIV Paediatric Study. AIDS 2004; 18(14): 1915-1924. (PubMed reference)
Gibb DM, Duong T, Leclezio VA, Walker AS, Verweel G, Dunn DT, for the Collaborative HIV Paediatric Study (CHIPS) Steering Committee and Sophia Children’s Hospital, Rotterdam, The Netherlands. Immunological changes during unplanned treatment interruptions of highly active antiretroviral therapy in children with human immunodeficiency virus type 1 infection. Paediatric Infectious Disease Journal 2004; 23(5): 446-450. (PubMed reference)
Gibb DM, Duong T, Tookey PA, Sharland M, Tudor-Williams G, Novelli V, Butler K, Riordan A, Farrelly L, Masters J, Peckham CS, Dunn DT, on behalf of the National Study of HIV in Pregnancy and Childhood (NSHPC) and the Collaborative HIV Paediatric Study (CHIPS). Decline in mortality, AIDS and hospital admissions in perinatally HIV-1 infected children in the UK and Ireland. BMJ 2003; 327: 1019. (Download paper)
CHIPS published papers resulting from collaborations with other studies
The Pursuing Later Treatment Options II (PLATO II) project team. Risk of triple-class virological failure in children with HIV: a retrospective cohort study. Lancet 2011; 377(9777): 1580-7 (PubMed reference)
Wittkop L, Gunthard HF, de Wolf F, Dunn D, Cozzi-Lepri A, de Luca A et al. Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroChoord-CHAIN joint project): a European multicohort study. Lancet Infectious Diseases 2011; 11(5): 363-71. (PubMed reference)
Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE), Mocroft A, Reiss P, Kirk O, Mussini C, Girardi E, Morlat P, Stephen C, De Wit S, Doerholt K, Ghosn J, Bucher HC, Lundgren JD, Chene G, Miro JM, Furrer H. Is it safe to discontinue primary Pneumocystis jiroveci pneumonia prophylaxis in patients with virologically suppressed HIV infection and a CD4 cell count <200 cells/microL? Clin Infect Dis. 2010 Sep 1;51(5):611-9. (Download paper)
Goetghebuer T, Haelterman E, Le Chenadec J, Dollfus C, Gibb DM, Judd A, Green H, Galli L, Faye A, Tomas Ramos J, Giaquinto C, Warszawski J, Levy J for the European Infant Collaboration group. Effect of early antiretroviral therapy on the risk of AIDS/death in HIV infected infants: the European Infant Collaborative Study. AIDS 2009; 23: 597-604. (PubMed reference)
Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study group. Response to combination antiretroviral therapy: variation by age. AIDS 2008; 22: 1463-1473. (Download paper)
Dunn DT, Gibb DM, Duong T for the HIV Paediatric Prognostic Markers Collaborative Study (HPPMCS). Predictive value of absolute CD4 cell count for disease progression in untreated HIV-1 infected children. AIDS 2006; 20:1289-1294. (PubMed reference)
Dunn DT, Gibb DM, Duong T et al. HIV Paediatric Prognostic Markers Collaborative Study. Use of total lymphocyte count for informing when to start antiretroviral therapy in HIV-infected children: a meta-analysis of longitudinal data. Lancet 2005;366:1868-1874. (Download pre-publication paper) (PubMed reference)
Charakida M, Donald AE, Green H, Storry C, Clapson M, Caslake M, Dunn DT, Halcox JP, Gibb DM, Klein NJ. Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation 2005; 112: 103-109. (PubMed reference)
Dunn DT, on behalf of the HIV Paediatric Prognostic Markers Collaborative Study. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. Lancet 2003; 362: 1605-1611. (Download pre-publication paper) (PubMed reference)
CONFERENCE PRESENTATIONS
Conference presentations 2010
Payne H, Donegan K, Okike I, Gibb DM, Doerholt K, Heath PT. Prevalence of vaccine-preventable infections among HIV-infected children in the UK and Ireland, 1996-2008. 28th Annual Meeting of the European Society for Paediatic Infectious Diseases, Nice 2010. (Poster) (Download Presentation)
Boyd K, Walker AS, Dunn D, Judd A, Pillay D, Menson E, Tudor-Williams G, Gibb DM. The Prevalence of Darunavir Associated Mutations in PI-naive and PI-experienced HIV-1 Infected Children in the UK. 17th Conference on Retroviruses and Opportunistic infections, San Francisco 2010. (Poster) (Download Presentation)
Conference presentations 2009
Judd A, Boyd K, Stöhr W, Dunn DT, Butler K, Riordan A, Gibb D. Effect of tenofovir disoproxil fumarate (TDF) on risk of renal impairment in HIV-1 infected children on antiretroviral therapy: nested case-control study. 16th Conference on Retroviruses and Opportunistic infections, Montreal 2009. (Poster) (Download Presentation)
Conference presentations 2008
Walker AS, Boyd KL, Doerholt K, Lyall EGH, Menson E, Butler K, Tookey PA, Riordan A, Shingardia D, Judd A, Tudor-Williams G, Gibb DM. To overdose or underdose? The question of Kaletra in the UK/Irish Collaborative HIV Paediatric Study (CHIPS). Ninth International Congress on Drug Therapy in HIV Infection. Glasgow, UK 2008. (Oral) (Download Presentation)
Boyd K on behalf of the Collaborative HIV Paediatric Study (CHIPS). Children and resistance to HIV: CHIPS data. 2nd Annual CHIVA Conference, Liverpool 2008. (Oral) (Download Presentation)
Kekitiinwa A, Lee K, Walker AS, Maganda A, Doerholt K, Lyall H, Butler K, Asiimwe A, Kline M, Gibb D. Initial growth, CD4 and viral load responses to HAART in Ugandan compared to UK/Irish HIV-infected children. 15th Conference on Retroviruses and Opportunstic Infections, Boston 2008. (Poster) (Download Presentation)
Conference presentations 2007
Kekitiinwa A on behalf of the Mulago Cohort Team and the CHIPS Steering Committee. Growth, CD4 and viral load responses to HAART in UK/ Irish and Ugandan HIV-infected children. INTEREST Conference, Uganda 2007.
Cliff D on behalf of CHIPS. Tenofovir use in CHIPS: audit report. British HIV Association Autumn Conference, London 2007 (Oral).
Doerholt K on behalf of CHIPS NSHPC HYPNET CHIC. Adolescent in CHIPS/linking to CHIC: Young persons (YP) leaving CHIPS are lost to follow up - what to do next? British HIV Association Autumn Conference, London 2007 (Oral). (Download presentation)
Doerholt K, Judd A, Tookey P, Sharland M, Riordan A, Menson E, Novelli V, Lyall H, Masters J, Tudor-Williams G, Duong T, Gibb DM. Morbidity, mortality and response to treatment in HIV-infected children in the UK and Ireland 1996-2006: a prospective cohort study. Royal College of Paediatrics and Child Health 11th Spring Meeting, York 2007. (Download presentation)
Foster C, Judd A, Doerholt K, Lyall H, Gibb DM, Tookey P, Dunn T. Young people with perinatally acquired HIV: a Transitioning UK cohort. British Association for Sexual Health and HIV Spring Meeting, Blackpool 2007 (Oral). (Download presentation)
Sabin C and the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study. Response to combination ART: variation by age. Abstract 528. 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles 2007 (Poster). (Download Presentation)
Conference presentations 2006
Judd A, Lee KJ, Duong T, Walker AS, Butler K, Donaghy S, Lyall H, Masters J, Menson E, Novelli V, Peckham C, Riordan A, Sharland M, Tookey P, Tudor-Williams G, Gibb DM. Exposure and response to highly active antiretroviral therapy (HAART) in ART naive children in the UK and Ireland. XVI International AIDS Conference, Toronto 2006 (Poster; abstract number THPE0106). (Download presentation).
Judd A and Doerholt K on behalf of the Collaborative HIV Paediatric Study (CHIPS) Steering Committee and the National Study of HIV in Pregnancy & Childhood (NSHPC). Characteristics and responses to ART in the CHIPS cohort, 1996-2006. British HIV Association Autumn Conference, London 2006 (Oral). (Download presentation)
Judd A, Duong T, Walker AS, Tookey PA, Sharland M, Riordan A, Lyall H, Masters J, Menson E, Tudor-Williams G, Butler K, Donaghy S, Novelli V, Peckham C, Gibb DM for the Collaborative HIV Paediatric Study and the National Study of HIV in Pregnancy and Childhood. Older and wiser: continued improvements in clinical outcome and highly active antiretroviral therapy (HAART) response in HIV-infected children in the UK and Ireland, 1996-2005. 12th Annual Conference of the British HIV Association, Brighton 2006 (Oral) (Download presentation); Royal College of Paediatrics and Child Health 10th Spring Meeting, York 2006 (Poster). (Download presentation)
Judd A, Duong T, Walker AS, Tookey P, Gibb DM on behalf of the National Study of HIV in Pregnancy and Childhood and the Collaborative HIV Paediatric Study Steering Committee. Trends in morbidity, mortality, and exposure and response to highly active antiretroviral therapy (HAART), in HIV-infected children in the UK and Ireland, 1996-2004. 10th International Workshop on HIV Observational Databases, Madrid 2006 (Poster).
Lee KJ, Lyall H, Walker AS, Sharland M, Judd A and Gibb DM. Wide disparity in switch to second-line therapy in HIV infected children in CHIPS. Eighth International Congress on Drug Therapy in HIV infection, Glasgow 2006 (Oral Paper PL 2.4). (Download presentation)
Lee KJ on behalf of the Collaborative HIV Paediatric Study (CHIPS) Steering Committee. Switch to second-line therapy in the CHIPS cohort. British HIV Association Autumn Conference, London 2006 (Oral). (Download presentation)
Shingadia D, Lee KJ, Pillay D, Walker AS, Tudor-Williams G, Judd A and Gibb DM. Viral load blip in HIV infected children from the CHIPS cohort: what do they mean? Eighth International Congress on Drug Therapy in HIV infection, Glasgow 2006 (Poster; abstract number P359). (Download presentation)
Conference presentations 2005
Menson EN, Walker S, Doerholt K, Duong T, Wells C, Sharland M, Gibb DM on behalf of the Collaborative HIV Paediatric Study. Extent of underdosage of antiretroviral therapy in HIV-infected children. Royal College of Paediatrics and Child Health 9th Spring Meeting, York 2005 (Oral plenary).
Conference presentations 2004
Doerholt K, Walker S, Sharland M, Riordan A, Novelli V, Tookey P, Cole T, Gibb DM. Long-term growth in previously untreated HIV infected children starting Highly Active Antiretroviral Therapy (HAART) in the Collaborative HIV Paediatric Study (CHIPS) in UK and Ireland. XV International AIDS Conference, Bangkok 2004 (Poster; abstract number TuPeB4424).
Doerholt K, Duong T, Sharland M, Tookey P, Butler K, Lyall H, Dunn D, Gibb DM. Poor virological response to HAART among infants in the Collaborative HIV Paediatric Study (CHIPS) in the UK and Ireland. XV International AIDS Conference, Bangkok 2004 (Oral; abstract number TuOrB1188).
Doerholt K, Duong T, Gibb DM on behalf of the CHIPS Steering Committee and the NSHPC. What happens to infants in the era of HAART in the UK and Ireland? 8th International Workshop on HIV Observational Databases, Montreaux 2004 (Closed meeting).
Foster CJ, Lyall EGH, Doerholt K, Duong T, Tookey PA, Sharland M, Tudor-Williams G, Novelli V, Butler K, Riordan A, Gibb DM on behalf of the Collaborative HIV Paediatric Study (CHIPS). HIV infected adolescents: an evolving UK cohort. British HIV Association 10th Anniversary Conference, Cardiff 2004 (Oral). (Download presentation)
Gibb DM, Dunn DT, Duong T, Galli L, Giaquinto C, Hughes M, Mofenson L, Moye J, Newell ML, Palumbo P, Rudin C, Shearer W. Predictive value of total lymphocyte count (TLC) for disease progression in untreated HIV-infected children in Europe and USA. XV International AIDS Conference, Bangkok 2004 (Oral; abstract number TuOrB1189).
Gibb D, Walker S, Doerholt K on behalf of the CHIPS Steering Committee. Variation in the effective dosage of antiretoviral drugs in children. 8th International Workshop on HIV Observational Databases, Montreux 2004 (Closed meeting).
Conference presentations 2003
Doerholt K, Duong T, Sharland M, Tookey P, Masters J, Gibb DM on behalf of CHIPS and NSHPC. Changes in vertically acquired paediatric HIV in UK and Ireland over calendar time: The Collaborative HIV Paediatric Study (CHIPS) and the National Study of HIV in Pregnancy and Childhood (NSHPC). Royal College of Paediatrics and Child Health 7th Spring Meeting, 2003 (Oral; abstract number G165).
Gibb DM, Walker AS on behalf of the Collaborative HIV Paediatric Study Group. Variation in the effect of HAART on short-term CD4 percentage and plasma HIV-1 RNA response according to age in children. 7th International Workshop on HIV Observational Databases, Fiuggi, Italy 2003 (Oral; closed meeting).
Conference presentations 2002
Duong T, on behalf of the HIV Paediatric Prognostic Markers Collaborative Study. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. XIV International AIDS Conference, Barcelona, 2002 (Poster; abstract number TuPec4849).
Duong T, McGee L, Sharland M, Tudor-Williams G, Novelli V, Butler K, Finn A, Tookey P, Peckham C, Dunn D, Gibb DM on behalf of CHIPS. Effects of antiretroviral therapy (ART) on morbidity and mortality of UK and Irish HIV infected children. Royal College of Paediatrics and Child Health 6th Spring Meeting 2002 (Poster; abstract number G210).
Leclezio V, Duong T, McGee L, Martinez-Alier N, Gibb D M, Verweel G. Treatment interruptions of HAART in paediatric HIV: effect on CD4 count. XIV International AIDS Conference, Barcelona 2002 (Poster; abstract number TuPeB4630).
Leclezio V, Duong T, McGee L, Martinez-Alier N, Gibb DM, Verweel G, on behalf of the Collaborative HIV Paediatric Study (CHIPS) Steering Committee. Treatment interruptions of HAART in paediatric HIV: effect on CD4 count. Royal College of Paediatrics and Child Health 6th Spring Meeting 2002 (Poster; abstract number G198).
Sharland M, Duong T, McGee L, Tudor-Williams G, Novelli V, Butler K, Finn A, Tookey P, Peckham C, Dunn D, Gibb D on behalf of the Collaborative HIV Paediatric Study (CHIPS). Effects of antiretroviral therapy (ART) on morbidity and mortality of UK and Irish HIV infected children. European Society for Pediatric Infectious Diseases 20th Annual Meeting, Vilnius, Lithuania 2002.
Walker AS, Gibb DM, McGee L, Dunn D, Tudor-Williams G, Sharland M, Butler K, Novelli V on behalf of the Collaborative HIV Paediatric Study (CHIPS). CD4 and HIV-1 RNA response following HAART in ART-naïve children. XIV International AIDS Conference, Barcelona 2002 (Poster; abstract number TuPeB4631).